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 23 May 2018

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News

Decreased quality of life in GERD patients with dyspepsia and IBS

Concomitant functional dyspepsia and IBS decreases health-related quality of life in GERD, show researchers in August's Scandinavian Journal of Gastroenterology.

News image

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An overlap between gastroesophageal reflux symptoms, functional dyspepsia and irritable bowel syndrome (IBS) has been reported.

Dr De Vries and colleagues from the Netherlands investigated the prevalence of functional dyspepsia and IBS in gastroesophageal reflux disease (GERD), and the effect on health-related quality of life.

Functional dyspepsia, irritable bowel syndrome prevalence, and health-related quality of life were assessed by means of questionnaires and proven with 24-hour pH-metry.

The research team sent the questionnaires to 215 referred and 48 non-referred GERD patients.

Health-related quality of life in 131 matched controls was used for comparison.

The team found in GERD patients, 25% had functional dyspepsia, 35% had irritable bowel syndrome, and 5% had both functional dyspepsia and irritable bowel syndrome.

GERD patients with functional dyspepsia had lower scores on 6 subscales
Scandinavian Journal of Gastroenterology

Only 35% had neither functional dyspepsia nor irritable bowel syndrome.

Among referred GERD patients, the researchers noted that the prevalence of functional dyspepsia and irritable bowel syndrome was higher.

Compared with controls, GERD patients without functional dyspepsia /irritable bowel syndrome had lower health-related quality of life scores on only 1 of the 9 Short Form-36 subscales.

The team observed that patients with GERD and functional dyspepsia had lower scores on 6 subscales.

GERD with irritable bowel syndrome patients had lower scores on 8 subscales compared with controls.

The researchers noted that patients with GERD, functional dyspepsia and irritable bowel syndrome had lower scores on 7 subscales compared with controls.

The team found that compared with patients with GERD only, GERD with functional dyspepsia patients had lower scores on 5 subscales.

GERD with irritable bowel syndrome patients had lower scores on 8 subscales compared with GERD patients alone.

In that comparison, patients with GERD, functional dyspepsia and irritable bowel syndrome had lower scores on 6 subscales.

Dr de Vries' team concluded, "In patients with proven GERD, functional dyspepsia and irritable bowel syndrome are more prevalent than in the general population."

"This prevalence is higher among care-seeking GERD patients."

"Only those GERD patients with concomitant functional dyspepsia /irritable bowel syndrome have a much lower health-related quality of life."

"This suggests that in GERD, when properly treated, health-related quality of life is affected mainly by concomitant functional disorders and not by GERD itself."

Scand J Gastroenterol 2007: 42(8): 951-6
31 July 2007

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