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 26 May 2018

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News

PPIs taken on-demand is effective for GERD treatment

This month's Alimentary Pharmacology & Therapeutics evaluates the treatment of GERD with PPIs taken 'on-demand'.

News image

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Proton pump inhibitors (PPI) therapy ‘on-demand' is often used as an alternative to continuous maintenance therapy in gastro-esophageal reflux disease (GERD).

Dr Pace and colleagues from Italy conducted a systematic review with the specific objectives to ascertain whether on-demand PPI therapy was effective in preventing symptomatic relapse.

The research team assessed the relative efficacy of on-demand vs continuous PPI maintenance strategy.

17 trials compared on-demand PPI vs continuous PPI therapy for GERD
Alimentary Pharmacology & Therapeutics

The team searched the Medline database, and the Cochrane Controlled Trials Register.

The researchers identified 17 randomized-controlled clinical trials comparing on-demand PPI vs placebo or on-demand vs continuous PPI therapy in GERD patients.

Out of the 17 studies, 5 investigated patients with non-erosive reflux disease.

A further 4 studies assessed patients with non-erosive reflux disease and mild esophagitis.

The team found 2 studies assessing patients with erosive esophagitis only, and 2 others included patients with uninvestigated GERD symptoms.

The team identified 4 further studies that were not investigating the effectiveness of the therapies but primarily pharmacoeconomic or quality of life parameters.

Dr Pace's team concluded , "On-demand therapy with currently available PPI appears to be effective in the long-term management of patients with non-erosive reflux disease or mild and uninvestigated forms of GERD, but not in patients with erosive esophagitis."

Aliment Pharmacol Ther 2007: 26(2): 195-204
12 July 2007

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