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Predictors of medication adherence in IBD

The latest issue of The American Journal of Gastroenterology investigators predictors of medication adherence in Inflammatory Bowel Disease

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Dr Jason Ediger and colleagues from Canada reported on cross-sectional medication adherence data from year 1 of the Manitoba Inflammatory Bowel Disease (IBD) Cohort Study.

The research team undertook a longitudinal, population-based study of multiple determinants of health outcomes in IBD in those diagnosed within 7 years.

33% of IBD patients were low adherers
The American Journal of Gastroenterology

The team assessed a total of 326 participants who completed a validated multi-item self-report measure of adherence.

The researchers also evaluated a range of adherence behaviors, demographic, clinical, and psycho-social characteristics by survey.

Adherence was initially considered as a continuous variable and then categorized as high or low adherence for logistic regression analysis.

The team used these categories to determine predictors of adherence behavior.

The researchers used a cutoff score of 20 out of 25 on the Medication Adherence Report Scale.

High adherence was reported by 73% of men and 63% of women.

For men, predictors of low adherence included diagnosis, and employment status.

The team found that for women, predictors of low adherence was younger age.

High scores on the Obstacles to Medication Use Scale strongly related to low adherence for both men and women.

The researchers observed that 5-aminosalicylic acid use was not related to adherence.

The team found that for women, immunosuppressant use versus no use was associated with high adherence.

Low trait agreeableness was associated with low adherence.

Dr Ediger's team concluded, "Approximately 33% of IBD patients were low adherers."

"Predictors of adherence differed markedly between genders, although obstacles such as medication cost were relevant for both men and women."

Am J Gastroenterol 2007: 102(7): 1417-26
02 July 2007

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