Nocturnal gastro-esophageal reflux diseases (GERD) can lead to esophageal mucosal injury and extra-esophageal complications.
Dr Ronnie Fass and colleagues from Arizona, USA compared the distribution of esophageal acid exposure during sleep time in non-erosive reflux disease.
The team enrolled 38 patients who had an abnormal pH test, erosive esophagitis and Barrett's esophagus.
Patients underwent endoscopy followed by 24-hour esophageal pH testing.
The investigative team assessed esophageal acid exposure every 2 hours of the sleep period.
|Barrett's patients showed the greatest decline during the sleep period|
|Alimentary Pharmacology & Therapeutics|
The investigators evaluated each period of 2 hours for acid reflux parameters.
All groups were matched by age, time from last meal and duration of sleep time.
All GERD groups demonstrated higher esophageal acid exposure in the first vs second half of the sleep period as determined by percent time pH less than 4.
The team observed that patients with Barrett's had a higher distribution of esophageal acid exposure than those with abnormal pH tests and erosive esophagitis.
Dr Fass' team commented, "Esophageal acid exposure generally declines throughout the sleep period regardless of GERD group."
"However, Barrett's esophagus patients demonstrated the greatest decline during the sleep period."