Dr Amnon Sonnenberg and colleagues from Oregon followed the time trends of mortality from gastric and duodenal ulcer in countries outside Europe.
The team compared these trends with previous reports of ulcer mortality from Europe and North America.
The research team assessed mortality data from 8 different countries.
These included Argentina, Australia, Chile, Hong Kong, Japan, Mexico, Singapore, and Taiwan.
The age-standardized death rates of individual countries were followed from 1971 to 2004.
Japan and Australia had mortality data for more than 50 years that provided the opportunity to conduct a birth-cohort analysis.
|Peak mortality from gastric ulcer occurred among generations born in 1875|
|The American Journal of Gastroenterology|
The researchers found that the data from all countries were characterized by a decline in gastric and duodenal ulcer mortality.
Except for Hong Kong, the team observed that mortality from gastric ulcer was higher than mortality from duodenal ulcer.
For Japan and Australia, mortality from gastric and duodenal ulcer displayed time trends that were consistent with an underlying birth-cohort phenomenon.
The risk of dying from gastric and duodenal ulcer increased in consecutive generations born between the mid- and the end of the 19th century.
The researchers noted that mortality risk of gastric and duodenal ulcers decreased in all subsequent generations.
The peak mortality from gastric ulcer occurred among generations born in 1875.
However, the team noted that peak mortality from duodenal ulcer occurred among generations born 10 to 20 years later.
Dr Sonnenberg's team concluded, "The ubiquitous decline in ulcer mortality in countries from different parts of the world is likely to be associated with a worldwide decline in the occurrence of Helicobacter pylori infection."
"The events accompanying the receding infection in developed countries must have similarly affected populations exposed to increasing standards of hygiene."