Dr Amnon Sonnenberg from Portland, Oregon performed a study to follow the time trends of mortality from gastric and duodenal ulcers in countries outside Europe.
He then compared the results with previous reports of ulcer mortality from Europe and North America.
Mortality data from eight different countries were analyzed, including Argentina, Australia, Chile, Hong Kong, Japan, Mexico, Singapore, and Taiwan.
|Mortality from gastric ulcer was higher than mortality from duodenal ulcer.|
| The American Journal of Gastroenterology |
The age-standardized death rates of individual countries were followed from 1971 to 2004.
Japan and Australia had mortality data for more than 50 years that provided the opportunity to conduct a birth-cohort analysis.
The data from all the countries were characterized by a decline in gastric and duodenal ulcer mortality.
With the exception of Hong Kong, mortality from gastric ulcer was higher than mortality from duodenal ulcer.
In Japan and Australia, mortality from gastric and duodenal ulcers displayed time trends that were consistent with an underlying birth-cohort phenomenon.
The risk of dying from gastric and duodenal ulcers increased in consecutive generations born between the mid- and the end of the nineteenth century and decreased in all subsequent generations.
The peak mortality from gastric ulcer occurred among generations born in 1875, whereas peak mortality from duodenal ulcer occurred among generations born 10-20 years later.
Dr Sonnenberg concluded that, "The ubiquitous decline in ulcer mortality in countries from different parts of the world is likely to be associated with a worldwide decline in the occurrence of H. pylori infection".
He also stated that, "The events accompanying the receding infection in developed countries must have similarly affected populations exposed to increasing standards of hygiene".