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 24 February 2018

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News

Alcohol relapse is not the main cause of liver transplant mortality

De novo malignancies are a greater cause of mortality than recurrent alcohol liver disease after liver transplants for alcoholic cirrhosis, shows May's American Journal of Gastroenterology.

News image

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Alcoholic liver disease is a leading indication for liver transplantation.

Dr Jérôme Dumortier and colleagues from France evaluated long-term results and survival prognostic factors of liver transplantation in this indication from a large cohort of patients.

The team assessed 305 consecutive patients with alcoholic cirrhosis who underwent liver transplantation in their center from 1990 to 2005.

There were 229 men and 76 women, with a median age of 50 years.

The research team analyzed clinical and biological variables with possible prognostic value.

The researchers found that the global survival rate was 93% at 1 year, 89% at 3 years, 84% at 5 years, and 73% at 10 years.

Recurrence of alcohol consumption occurred in 12%
American Journal of Gastroenterology

The global survival rate was similar to that of patients transplanted for other cirrhosis.

The research team observed recurrence of alcohol consumption in 12% patients.

De novo cancer occurred in 12% patients after liver transplantation.

Univariate analysis disclosed that male gender, history of smoking, and de novo carcinoma were significant survival prognostic factors.

Dr Dumortier's team concluded, "Our results strongly confirm that alcoholic liver disease is an excellent indication for liver transplantation."

"However, long-term survival is reduced because of other target-organ damage of both alcohol and tobacco."

"Aero-digestive malignancies are especially a greater cause of morbidity and mortality than recurrent alcohol liver disease."

Am J Gastroenterol 2007: 102(5):1032-41
16 May 2007

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