Helicobacter pylori infection is considered among the causative factors of urticaria and angioedema.
A previous study on 65 patients in 2001 reported that successful eradication of H. pylori reduces the number of attacks in patients with hereditary angioedema.
Dr Henriette Farkas and colleagues reinvestigated the relationship between H. pylori infection and the attack rate in the framework of an international collaborative study.
|Eradication of H. pylori results in fewer attacks|
Within the framework of the PREHAEAT project launched by the European Union, a further 152 patients were studied in 7 collaborating centers.
The research team followed up participants of the earlier study were followed.
The researchers then assessed whether there is any relationship between H. pylori infection and the occurrence of attacks in patients suffered from hereditary angioedema.
The team found that the proportion of patients experiencing frequent abdominal attacks was higher among the H. pylori-infected participants who underwent eradication.
Successful eradication of H. pylori significantly reduced the number of attacks in these patients as well.
The team followed up 9 subjects of the previous study who underwent eradication therapy for dyspepsia for an additional 4 years.
In these patients, attack frequency remained consistently low.
Dr Farkas' team comments, "As shown by experience from the Hungarian trial, and our international trial, the number of frequent, edematous abdominal attacks may decrease following the eradication of H. pylori from hereditary angioedema patients."
"Therefore, screening of patients with hereditary angioedema for H. pylori infection seems warranted."
"Eradication of H. pylori may lead to a marked reduction in disease severity."