It has been suggested that the post-liver transplantation survival rate of patients with Hepatitis C virus infection has declined in recent years.
Dr Paul Thuluvath and colleagues from Baltimore compared the outcome of post-liver transplantation in patients with Hepatitis C at various time intervals between 1991 and 2001.
|Survival rates of non-Hep C recipients improved during 1998 and 2001|
The team used United Network for Organ Sharing data to compare the post-liver transplantation survival of adult patients with and without Hepatitis C.
The investigative team identified 37,101 patients who underwent post-liver transplantation during the study period.
Of these, 28,193 patients were eligible for the study.
On the basis of the time of transplantation, patients were divided into 3 groups.
Period 1 ranged between 1991 and 1993, Period 2 from 1994 and 1997, and Period 3 from 1998 and 2001.
The team adjusted patient and graft survival rates for other known confounding variables that influenced outcomes.
The investigators found that the 3-year patient survival rate was lower in Hepatitis C patients compared with non-Hepatitis C recipients.
The graft and patient survival of Hepatitis C patients remained unchanged during study periods 1 to 3, respectively.
However, the team noted that graft and patient survival rates of non-Hepatitis C recipients improved markedly during study periods 2 and 3 compared with period 1.
Dr Thuluvath's team concluded, "The graft and patient survival has remained unchanged between 1991 and 2001 in Hepatitis C recipients."
"However, during the same period, there was a great improvement in survival among non-Hepatitis C recipients."