There are discrepant estimates of incidence rates of irritable bowel syndrome (IBS) after gastroenteritis.
Dr Ana Ruigómez and colleagues from Spain performed a cohort study to quantify this risk in community subjects.
The researchers identified factors acting as modifiers of this effect.
|There was a 2-fold greater risk of IBS after bacterial gastroenteritis|
|Clinical Gastroenterology & Hepatology|
The team identified patients aged 20 to 74 years with a first ever episode of bacterial gastroenteritis during 1992 to 2001.
The research team excluded patients with a history of bowel disease and cancer, resulting in a cohort of 5894 individuals with gastroenteritis.
From the same source population, a control group free of gastroenteritis was sampled.
The research team followed up the 2 cohorts to identify incident cases of IBS.
A nested case-control analysis was performed to quantify the role of potential risk factors.
The researchers found that during a mean follow-up period of 4 years, 1105 patients developed IBS.
The incidence rate of IBS after an episode of bacterial gastroenteritis was 98 per 10,000 person-years.
The team observed that the incidence rate of IBS was 45 per 10,000 person-years in the comparison cohort.
The adjusted relative risk of IBS associated with bacterial gastroenteritis was 2 compared with the control cohort.
The team noted that the nested case-control analysis adjusting for additional risk factors produced similar results.
The risk of IBS after gastroenteritis was increased significantly in patients with depression, anxiety, and stress or sleep disorders.
In addition, the researchers found that prior gastrointestinal morbidity, or prolonged use of antibiotics increased the risk of IBS after gastroenteritis.
Dr Ruigómez's team concluded, "The risk of IBS in community individuals after having bacterial gastroenteritis was 2-fold greater in the general population."
"Pre-existing psychologic and gastrointestinal comorbidities independently increase this risk of developing IBS."