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News

MALT lymphoma remission with H pylori eradication

H pylori eradication for low-grade gastric mucosa-associated lymphoid tissue lymphoma is more successful in inducing remission in distal disease, finds this month's British Journal of Cancer.

News image

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A series of studies has shown that Helicobacter pylori eradication induces remission in most patients with low-grade gastric mucosa-associated lymphoid tissue (MALT).

Korea is a well-known H pylori endemic area.

However, there have been few reports about the effect of bacterial treatment on the gastric mucosa-associated lymphoid tissue lymphoma in Korea.

Complete remission was obtained in 85% after H pylori eradication
British Journal of Cancer

Dr Kim and colleagues from Korea assessed a total of 111 H pylori-infected patients.

The patients were prospectively enrolled in Seoul National University Hospital.

The research team reported that 99 patients were completely followed up.

After H pylori eradication, tumoral response was evaluated by endoscopy and histopathology every 2 to 3 months till complete remission.

The team also evaluated tumoral response every 6 months after achieving complete remission.

Median follow-up period was 41 months.

The team found that H pylori was successfully eradicated in all patients.

Complete remission was obtained in 85% of these patients.

The median time to reach complete remission was 3 months.

The researchers found that 94% of patients in complete remission were in continuous complete remission.

The team observed that 5 patients with complete remission relapsed after 10 to 22 months without the evidence of H pylori reinfection.

Cumulative recurrence rate was 2%, 8% and 9% at 1, 2 and 3 years, respectively.

The researchers noted that tumors were mainly located in distal stomach.

Tumors in distal stomach were associated with more favorable response than those in proximal stomach.

Dr Kim‘s team concludes, "Most patients with low-grade gastric mucosa-associated lymphoid tissue lymphoma treated by H pylori eradication have a favorable long-term outcome."

"This offers a real chance of cure."

"Tumor location could be a predictive factor for remission following H pylori eradication."

Br J Cancer 2007: 96(9): 1324-28
09 May 2007

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