The widespread use of proton pump inhibitors for gastro-esophageal reflux disease (GERD) could result in a decline in new as well as recurrent GERD disease-related esophageal strictures.
The temporal trends of strictures have not been examined in population-based studies.
|Recurrent dilation within 1 year declined from 16% to 8%|
|Alimentary Pharmacology & Therapeutics|
Drs El-Serag and Lau from Texas examined the temporal trends in strictures.
The team calculated age-adjusted incidence rates of new esophageal strictures with or without esophageal dilation.
The team evaluated a sample of Medicare beneficiaries between 1992 and 2000.
The team also assessed recurrent dilations recorded at least 3 months after a new stricture or the preceding recurrent stricture.
The research team found that the age-adjusted rates for strictures accompanied with dilation declined by approximately 11% from 215 per million to 192 per million.
New esophageal strictures with dilation declined as a proportion of all upper endoscopies procedures, from 3% to 2%.
The researchers found that recurrent dilation within 1 year declined dramatically from 16% in 1992 to 8% in 2000.
Using a multivariable proportional hazards model, the team found a 30% risk reduction of recurrent esophageal strictures.
Dr El-Serag's team concluded, “This population-based study indicates that the incidence of new as well as recurrent esophageal strictures has been declining.”
“In the face of rising incidence of other GERD-related complications, it is important to understand the explanation of the present observations.”