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 21 May 2018

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News

Hep C resolves in genotype 2 or 3 patients after antiviral therapy

The latest Alimentary Pharmacology & Therapeutics reports late resolution of Hep C in genotype 2 or 3 patients with low viral load at the end of therapy.

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Persistence of Hepatitis C virus in serum is assured after any course of antiviral therapy that failed to obtain a sustained virological response.

Dr Siciliano and colleagues from Italy evaluated the long-term effect on serum Hepatitis C virus-RNA in patients on a course of pegylated-interferon and ribavirin therapy who were unable to obtain sustained response.

Hep C-RNA clearance rate is higher in genotype 2 and 3 non-responders
Alimentary Pharmacology & Therapeutics

The team determined serum Hepatitis C virus-RNA at monthly intervals in 68 non-responders, breakthroughs and relapsers.

The researchers also evaluated 52 naïve controls.

The team enrolled the patients in a 5-year study.

The researchers found that 5 genotype 2 or 3 patients cleared Hepatitis C virus-RNA after the end of therapy or relapse.

The patients remained negative until the end of follow-up.

Hepatitis C virus-RNA clearance rate in genotype 2 and 3 non-responders, breakthroughs or relapsers was higher than in controls with the same genotypes.

The team noted that Hepatitis C virus-RNA at the end of treatment or at relapse was less than 105 IU/mL in the 5 patients who cleared the virus.

None of genotype 1 or 4 patients cleared Hepatitis C virus-RNA during follow-up.

Dr Siciliano's team concludes, “Late resolution of Hepatitis C virus infection is possible in genotype 2 or 3 patients with low viral load at the end of therapy or at relapse.”

“In these subjects, Hepatitis C virus-RNA monitoring is advisable during the first year after therapy.”

Aliment Pharmacol Ther 2007: 25(9): 1039-46
20 April 2007

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