Preoperative radiotherapy combined with total mesorectal excision has provided excellent local control in the treatment of rectal cancer.
Dr William Orrom and colleagues from Canada retrospectively reviewed 448 patients treated at the team's regional cancer center with definitive surgery for rectal cancer from 1998 to 2004.
|Preoperative radiotherapy had a recurrence rate of 4%|
|American Journal of Surgery|
The research team compared the results with a similar study carried out in their region from 1988 to 1998.
The team determined any changes in treatment methods, recurrence rates, and survival.
The research team analyzed patient factors including sex, age, type of surgery, and adjuvant strategy.
Tumor factors that were analyzed included level, stage, and grade.
The team recorded the presence of local recurrence was recorded, and determined overall survival.
The researchers found that the local recurrence rate was 8% compared with 13% in the previous study.
Patients treated with preoperative radiotherapy had a recurrence rate of 4%.
The team noted that the type of surgical therapy had no significant effect on local recurrence.
There was no significant change in overall survival between the present study and the previous one.
Dr Orrom and team concluded, “Preoperative radiotherapy is used more frequently in our region.”
“It has resulted in a decrease in the local recurrence rate compared to our previous retrospective review.”
“There was no change in local recurrence seen in those patients treated with operative management alone.”
“This study supports the use of preoperative radiotherapy in the management of rectal cancer.”