Non-invasive markers of liver fibrosis have recently been developed as an alternative to liver biopsy.
Dr Vincent Leroy and colleagues from France compared the diagnostic performance of 6 scores.
The investigative team evaluated MP3, Fibrotest, Fibrometer, Hepascore, Forns' score, and Aspartate Aminotransferase to Platelet Ratio Index.
|The positive predictive value ranged from 55% to 94%|
|Journal of Hepatology|
The team studied 180 chronic Hepatitis C patients.
Liver fibrosis was staged according to the METAVIR scoring system.
The overall diagnostic performance of scores was determined by area under the receiver operating characteristic curves.
The team noted that for discriminating F0F1F2 vs F3F4, the area under the receiver operating characteristic curve was 0.8 for Forns' score.
For discriminating F0F1F2 versus F3F4, area under the receiver operating characteristic curve was 0.9 for Fibrometer.
The team predicted significant or extensive fibrosis in 10% to 86% of patients.
The investigators found that the positive predictive value ranged from 55% to 94%.
The team demostrated statistical independence for MP3, Fibrotest and the Aspartate Aminotransferase to Platelet Ratio Index.
The investigators then evaluated diagnostic performance of paired-combination scores.
The best combinations could select 33% of patients for whom fibrosis could be predicted with more than 90% of certainty.
Dr Leroy's team concluded, “Current non-invasive scores give reliable information on liver fibrosis in 33% of chronic Hepatitis C patients, especially when used in combination.”