Dr Canavan and colleagues from England performed a meta-analysis of published literature reporting standardized mortality ratios for Crohn's patients.
The team conducted a medline search to identify relevant papers from 1970 to date.
When 2 papers reviewed mortality of a patient group at different times, the later publication was used.
|The standardized mortality ratio in Crohn's disease is 1.5|
|Alimentary Pharmacology & Therapeutics|
The researchers identified 13 papers.
Of these, 3 studies reported standardized mortality ratios below 1, and 2 other studies had confidence intervals including 1.
The team found that all other studies reported mortality higher than the general population.
Meta-analysis using a random effects model showed that the pooled estimate for standardized mortality ratios in Crohn's disease is 1.5.
The researchers undertook meta-regression to show that the standardized mortality ratio for these patients had decreased slightly over the past 30 years.
However, the team reported that this decrease was not statistically significant.
Dr Canavan's team concluded, “Assessing evidence from original studies and conducting a meta-analysis shows age-adjusted mortality risk from Crohn's disease is over 50% greater than the general population.”
“Mortality has improved since the condition was first recognized.”
“However, further evaluation of the patients studied in the cohorts included here is necessary to assess more recent changes in clinical practice.”