Dr Joe West and colleagues from England explored whether the excess mortality in celiac disease is related to the disease and duration of gluten exposure before diagnosis.
The research team examined the long-term mortality experience of people with celiac disease diagnosed as children and as adults.
The team followed 285 children and 340 adults diagnosed with celiac disease until death, loss to follow-up, or 2004.
|All-cause mortality was increased 3-fold in children|
|The American Journal of Gastroenterology|
The research team calculated standardized mortality ratios.
The researchers found all-cause mortality more than 5 years after diagnosis was increased 3-fold in children.
In adults, all-cause mortality more than 5 years after diagnosis was increased by 38%.
This excess mortality in children was primarily because of an increased risk of death from accidents, suicide, and violence.
Cancer, and cerebrovascular disease also contributed to the excess mortality in children.
Dr West's team concluded, “Children diagnosed with celiac disease had a 3-fold increased risk of long-term mortality.”
“This is in marked contrast to the experience of adult celiac disease where the long-term increase of mortality was modest.”
“The increased mortality in children from external causes may reflect behavioral change associated with coping with a chronic disease and its treatment.”