Earlier studies regarding the risk of colorectal cancer in women with a prior diagnosis of gynecologic malignancies have revealed conflicting results.
Dr Radhika Srinivasan and colleagues from England undertook a retrospective cohort study to further clarify this association.
The team of doctors used the General Practice research database of the United Kingdom.
Patients with a prior diagnosis of ovarian, uterine, or cervical cancers were compared with control patients without a prior gynecologic malignancy.
The doctors' primary outcome was a diagnosis of colorectal cancer.
The team used Poisson regression analysis to assess the effects of potential confounders.
|5 in 10 cases were diagnosed with colorectal cancer within 6 months |
|Journal of Clinical Gastroenterology|
The doctors evaluated 1995 ovarian, 1348 uterine, and 1101 cervical cancer patients.
The team then assessed 7980, 5392, and 4404 matched control patients, for each respective patient group.
The adjusted incidence rate ratio of colorectal cancer among ovarian cancer patients was 2.9.
The doctors noted that 5 of 10 cases of colorectal cancer in ovarian cancer patients were diagnosed within 6 months of the cancer diagnosis.
The team found that the adjusted incidence rate ratio was 8.
Excluding the initial 6 months of follow-up after the diagnosis of ovarian cancer, the adjusted incidence rate ratio was 1.6.
The team noted that the adjusted incidence rate ratio of colorectal cancer in patients with a prior diagnosis of uterine and cervical cancer was 0.8, and 1.50, respectively.
Dr Srinivasan's team commented, “Women with a prior diagnosis of ovarian cancer are at an increased risk of colorectal cancer.”
“The risk of colorectal cancer was not increased among patients with a prior history of uterine and cervical cancer.”