Hepatic venous pressure gradient has prognostic value in complications and survival of patients with liver cirrhosis.
The relationship between hepatic venous pressure gradient, and acute alcoholic hepatitis outcomes has not been defined.
The relationship between hepatic venous pressure gradient and features of portal hypertension syndrome in this setting has also not been assessed.
Dr Rincon and colleagues from Spain evaluated the prognostic value of hepatic venous pressure gradient.
The research team also analyzed the degree of portal hypertension and hyperdynamic circulation in patients with severe acute alcoholic hepatitis.
|66% with hepatic venous pressure gradients more than 22 mmHg died|
|Alimentary Pharmacology & Therapeutics|
The team performed early measurements of hepatic venous pressure gradients in 60 patients with severe acute alcoholic hepatitis.
The researchers then compared these results with the hemodynamic findings of 37 liver transplant candidates, and 29 alcoholic or viral end-stage cirrhosis patients.
The research team noted that 38% of patients died during hospitalization.
Portal hypertension, and hyperdynamic circulation were more severe in acute alcoholic hepatitis patients.
The researchers observed that hepatic venous pressure gradient was greater in non-survivors.
Only 13% of patients with hepatic venous pressure gradients of 22 mmHg died from the episode of acute alcoholic hepatitis.
The team observed that 66% of patients with hepatic venous pressure gradients more than 22 mmHg died from such an episode.
Encephalopathy, and Model for End-Stage Liver Disease score more than 25 were independently associated to in-hospital mortality.
The research team found that hepatic venous pressure gradients more than 22 mmHg was independently associated to in-hospital mortality.
Dr Rincon's team concluded, “Early measurement of hepatic venous pressure gradient provides important prognostic information on the short-term outcome of patients with severe acute alcoholic hepatitis.”
“In addition, model for end-stage liver disease score also seems to be a strong prognostic factor in these patients.”