A team from Detroit, Michigan, USA, compared the efficacy and safety of propofol and general anesthesia in children undergoing elective gastrointestinal (GI) endoscopy.
A total of 50 pediatric patients aged 2 to 21 years, in whom elective GI endoscopy under general anesthesia was required, were randomized to receive propofol (n = 25) or standard inhalational anesthesia (n = 25).
The parameters monitored in the two groups were the time until wake-up after completion of the procedure, and the total time for anesthesia and recovery.
Adverse events during the procedures were noted with each agent.
The mean time until wake-up in the propofol group was 30 minutes, and 19 minutes in the anesthesia group.
With stratification into four age groups, it was noted that the youngest children, those 2 to 5 years of age, took the longest to awaken with propofol compared with inhalational anesthesia. In the other age groups the differences were not statistically significant.
In contrast, the mean total time for anesthesia and recovery in the propofol group was 107 minutes, and 139 minutes in the inhalational anesthesia group.
| Less restlessness and agitation occurred in those receiving propofol.
| Gastrointestinal Endoscopy |
The researchers found that the total time for anesthesia and recovery was longest in the group 5 to 8 years of age who had inhalational anesthesia.
Changes in systolic and diastolic blood pressure occurred with equal frequency in both groups.
Transient apnea was noted in 20% of patients receiving propofol.
In addition, restlessness and agitation occurred in 52% of patients receiving inhalational anesthesia, compared with 8% in the propofol group.
Dr Rajiv Kaddu, of the Children's' Hospital of Michigan, Detroit, concluded on behalf of the group, "Propofol, administered by an anesthesiologist, is an excellent and safe intravenous anesthetic agent for pediatric GI endoscopy."