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 22 November 2017

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News

Low ileal interleukin-10 concentrations predict endoscopic recurrence in Crohn's

Low ileal interleukin-10 mRNA concentrations are predictive of endoscopic recurrence in patients with Crohn's disease, claim international researchers.

News image

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The team evaluated if ileal tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1-beta, or IL-10 mRNA levels, measured at the time of surgery, predict endoscopic recurrence in Crohn's disease.

They published their findings in the latest issue of Gut.

The researchers also assessed whether ileal IL-10 levels are associated with particular IL-10 promoter alleles.

Ileal biopsies were obtained preoperatively from the healthy neoileum of patients undergoing a right ileocolectomy for Crohn's disease.

Mucosal TNF-alpha, IL-1-beta, and IL-10 mRNA levels were quantified by competitive polymerase chain reaction.

In addition, IL-10.G promoter haplotypes were analyzed using a polymorphic dinucleotide repeat in the IL-10 promoter region.

Three months after surgery, 53% of patients had endoscopic recurrence, while 47% remained free of disease.

Distribution of IL-10.G haplotypes cannot predict the postoperative evolution of Crohn's.
Gut

The risk of endoscopic recurrence was found to be correlated with ileal IL-10 mRNA concentrations.

Endoscopic recurrence occurred more frequently in patients classified as low IL-10 producers than in those that were high producers (80% vs 40%).

Patients with at least one of the two alleles G7-8 or G10-13 produced, respectively, higher and lower ileal IL-10 mRNA.

The researchers found that the distribution of IL-10.G microsatellite genotypes was similar in patients with or without endoscopic recurrence.

Author B. Meresse, of the Regional University Hospital of Lille, France, concluded on behalf of fellow colleagues, "Low ileal IL-10 mRNA concentration is a good marker of endoscopic recurrence in Crohn's disease.

"However, the distribution of IL-10.G haplotypes cannot predict the postoperative evolution of the disease."

Gut 2002; 50(1): 25-8
10 January 2002

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