Researchers from Clamart, France, investigated the influence of excessive alcohol consumption on the occurrence of high-risk polyps (adenoma ≥ 10 mm, villous component, high-grade dysplasia) or colorectal cancer among patients with adenomas.
Three groups of patients, with at least one colorectal adenoma, were included in the case-control study.
The first group consisted of 401 heavy drinkers (group HD, mean daily alcohol intake of 117 g/day for a mean duration of 22 years), with a mean age of 57 years (78% men).
In the second group, there were 152 patients suffering from irritable bowel syndrome (IBS), aged 61 years (57% male).
| Heavy drinkers almost twice as likely to develop high-risk adenomas than IBS patients.
The third group comprised of 108 patients with a family history (FH) of colorectal adenoma or cancer, aged 55 years (64% male).
Exclusion criteria were anemia, hematochezia, and personal history of colorectal adenoma or cancer. For groups HD and IBS, those with a family history of colorectal adenoma and/or cancer were also excluded.
After age and sex adjustment, the likelihood of having an adenoma ≥ 10 mm was higher in group HD than in the IBS group (odds ratio [OR] 1.8).
The team found that the likelihood of having high-risk adenomas or cancer was higher in group HD compared with the IBS group (OR 1.6) and the FH group, although this was not significant (OR 1.6).
The probability of having an adenoma with high-grade dysplasia or cancer was found to be higher in group HD than in the IBS group (OR 1.7) or group FH, although this was not significant (OR 3.7).
Author Marc Barbou, of Antoine Béclére Hospital, Clamart, concluded on behalf of his group, "In patients with at least one colorectal adenoma, excessive alcohol consumption increases the likelihood of developing high-risk adenomas or colorectal cancer."