The team investigated whether serum bile acids can be reliably used to diagnose acute rejection after liver transplantation.
They reported their findings in the December issue of Transplant International.
Serum bile acid concentration, bilirubin, and transaminases were measured in 41 patients who underwent liver transplantation.
Group I (n = 19) patients were without acute rejection, whereas Group II (n = 22) patients showed acute rejection.
Bile acid concentrations in Group II showed a highly significant threefold increase, 3 days prior to biopsy.
Successful antirejection treatment was correlated with a statistically significant decrease of serum bile acid 1 day after initiation of therapy.
| Bilirubin and transaminase levels did not correlate with acute rejection.
| Transplant International |
Patients without acute rejection showed a baseline bile acid concentration at the time of biopsy.
The researchers found that bilirubin and transaminases did not show any statistically significant correlation to acute rejection.
Infection was not found to lead to a significant bile acid increase.
Author H. Janßen, of the Universitätsklinikum Essen, Essen, Germany, concluded on behalf of the group, "Our study shows that serum bile acids monitored after liver transplantation can easily be used to detect acute rejection and at the same time they reflect the success of antirejection therapy."