Researchers from Crete, Greece, studied the role of lipoprotein (a), in conjunction with lipids and apolipoproteins, in ulcerative colitis (UC) and Crohn's disease (CD) patients.
Lipoprotein (a) is recognized as a risk factor for arterial and venous thrombosis, a property that might be related to its structural similarity to plasminogen.
Since patients with inflammatory bowel disease (IBD) frequently suffer from thromboembolic events, the team decided to study the role of lipoprotein (a).
A total of 129 consecutive fasting Greek patients with IBD (66 with UC and 63 with CD) and 66 matched healthy controls were enrolled in the study.
Lipoprotein (a), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoprotein A-1, and apolipoprotein B-100 were determined in the sera of each subject.
In CD patients, the mean serum lipoprotein (a) level was significantly higher than in control patients (41.2 mg/dl vs 22.9 mg/dl).
| Raised lipoprotein (a) levels may increase thrombosis risk in Crohn's patients.
| European Journal of Gastroenterology & Hepatology |
Mean apolipoprotein A-1 and apolipoprotein B-100 levels were significantly lower in CD patients than in the controls.
The researchers found that, in UC patients, the mean levels of lipoprotein (a) and apolipoprotein A-1 were not significantly different from the controls, but the levels of apolipoprotein B-100 were significantly lower.
Raised levels of lipoprotein (a) of greater than 30 mg/dl were found in 29 CD patients (46%), 15 UC patients (23%), and 11 control patients (17%).
Patients with active CD were discovered to have significantly higher mean lipoprotein (a) and lower apolipoprotein A-1 than patients with non-active disease.
Ioannis E. Koutroubakis, of the University Hospital Heraklion, Crete, concluded on behalf of fellow authors, "Our results suggest that Crohn's disease patients have different lipoprotein (a) and apolipoprotein patterns compared to ulcerative colitis patients and healthy controls.
"These changes in Crohn's disease patients may possibly expose them to a higher risk of thrombosis."