Xanthelasma.These lesions, which are common the the upper gastrointestinal tract, are seen as small white or yellow plaques (Fi. 2.458), and may be multiple. Although they contain lipid-laden macrophages (Fig. 2.459) they do not correlate with the presence of hypercholesterolaemia. Their importance lies in differential diagnosis: histologically they may be confused with signet ring cell-type carcinoma.
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