Herpes simplex in the esophagus.
Herpetic lesions originate as vesicles; when these collapse the appear changes to shallow craters (Fig. 2.232). Simple staining of biopsy material with haematoxylin and eosin shows multinucleate cells with ‘glassy' nuclei, the typical cytopathic effect of H. simplex (Fig. 2.233a). Figure 2.233b shows positive staining with anti-H. simplex antibody.
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