Tylosis and esophageal cancer.
Tylosis (focal non-epidermolytic palmoplantar keratoderma: NEPPK) on
the soles of the feet and palms of the hands. There is thickening of
the skin. This patient came from a family with a strong history of
esophageal cancer. In these high-risk families the tylosis esophageal
cancer (TOC) gene locus has recently been mapped. It has been
postulated that the same deleted tumor suppressor gene may also be
deleted in other sporadic cases of esophageal cancer.
Iwaya T, Maesawa C, Ogasawara S, Tamura G. Tylosis esophageal cancer locus on chromosome 17q25.1 is commonly deleted in sporadic human esophageal cancer. Gastroenterology 1998 Jun;114(6):1206-10.
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