Erythema nodosum.This disorder characteristically affects the lower limbs and is due to inflammation of small blood vessels in the deeper dermis and subcutaneous tissue. Typically there are tender red swellings. This disease occurs in association with ulcerative colitis and Crohn's disease as well as streptococcal infection, leprosy, tuberculosis, sarcoidosis and drug therapy. Many other associations have been described. The activity of erythema nodosum usually mirrors that of the underlying disease. The lesions tend to leave residual bruising before healing over a period of 2-4 weeks. When occurring in association with inflammatory bowel disease, corticosteroid treatment reduces the swelling, tenderness and fever but does not hasten the clearing of the lesions.
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