Anal carcinoma.A large polypoid anal tumor with ulcerating components has developed in this elderly female. A large proportion of HIV positive men with a history of receptive anal intercourse, develop human papilloma virus infection which is a potent risk factor for anal cancer. Occasional patients with perianal Crohn's disease develop anal cancer. This is a squamous carcinoma which is normally managed by radiotherapy plus or minus chemotherapy, followed by a surgical approach when appropriate.
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