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Colonoscopy

Editors: Jerome Waye, Christopher Williams & Douglas Rex


9. Pediatric colonoscopy

Marvin E. Ament & George Gershman

Top of page Synopsis  Next section

Since its introduction almost forty years ago, colonoscopy has become a routine procedure, not only for adults, but pediatric patients with rectal bleeding, chronic diarrhea, change in stool caliber, and chronic lower abdominal pain. It is safely used in all groups of children, including newborns.

Although the instruments are similar, pediatric colonoscopy is different from colonoscopy in adults, in many aspects such as preparation, sedation, technique, and spectrum of therapeutic manipulations.

Top of page Indications for colonoscopy  Previous section Next section

Indications for diagnostic and therapeutic colonoscopy are listed in Fig. 1. Although colon cancer is not one of the usual indications for colonoscopy in children, colonoscopy and biopsy are performed for surveillance for detection of malignancy in patients with long-standing inflammatory bowel disease.

Patients who have undergone small intestinal transplantation may need to undergo ileoscopy and/or colonoscopy to obtain specimens from transplanted bowel to look for rejection and evidence of lymphoproliferative disease.

Top of page When diagnostic colonoscopy is not indicated  Previous section Next section

Colonoscopy is not indicated in patients with:

  • acute self-limited diarrhea;
  • gastrointestinal bleeding with a demonstrated upper gastrointestinal source;
  • stable recognized irritable bowel syndrome;
  • chronic-nonspecific abdominal pain;
  • constipation with or without impaction;
  • inflammatory bowel disease that is responding to treatment.

Diagnostic colonoscopy is absolutely contraindicated (Fig. 2) in anyone with fulminant colitis, toxic megacolon, or suspected perforated viscus. Recent intestinal resection represents a possible contraindication to the examination. However patients with acute severe colitis in which cultures are negative for bacterial pathogens and parasites, such as E. histolytica and Trichurus trichura, should have an examination of the rectum and distal sigmoid colon to help establish whether they have a specific type of colitis. In such cases, limiting the area viewed as indicated does not pose an undue risk. There are times when direct visualization of the mucosa gives a specific diagnosis such as when pseudomembranes are seen or punched out ulcers can be visualized.

Physicians should not consider doing colonoscopy in patients who have chronic or recurrent abdominal pain without other signs and symptoms, such as weight loss, failure to grow, loss of appetite, perianal disease, and positive indicators for inflammatory bowel disease, such as an elevated sedimentation rate, increased C reactive protein, and positive screening panel for inflammatory bowel disease.

Top of page Preparation of the patient for colonoscopy  Previous section Next section

Explanation  Previous section Next section

The risks and benefits of colonoscopy are reviewed with the family usually at the time that the procedure is scheduled. At that time questions and answers about the procedure may be discussed.

Preparing infants and children for colonoscopy can be difficult. Children who are less than school age may not understand why they are asked to have a restrictive diet and a simple explanation of why the test is being done is all that should be provided. The physician should try to use words that the child will understand in order to clarify why they are going to be tested. The physician and parents need to simply tell the child they are going to have a test to look at where their 'poop' comes from and it has to be clean inside to take a good look.

In school-age children and in adolescents fuller explanations may be provided depending on the level of sophistication of the child. It is useful to show the children and parents diagrams of the rectum and colon and distal small bowel to make them aware of what is going to be examined. Providing such knowledge ahead of time may make the child or adolescent more amenable to the procedure and more cooperative in preparing for the examination. It may be helpful to show pictures of the instruments used and simple diagrams of what may be normally seen.

Children at any age should be told that they will be given an intravenous infusion through which they will receive medications to make them sleep and to minimize any pain or discomfort.

Because most colonoscopists use medication to alter memory such as Valium or Versed the child should be told they will have little memory of their procedure other than going to sleep and that they will have little or no pain during the procedure.

Most children will be reassured by having the information that they will have devices attached to their fingers and arms, which measure their blood pressure or how hard their heart pumps, how fast their heart is beating, and the rate or speed at which they are breathing. Older individuals can be told that devices will be used to tell how much oxygen is in their blood. Apprehension will be diminished by informing children of all ages that when they awake from their sleep their parent or parents will be nearby.

Most children, but not all, will accept the preprocedure explanation well and this will serve to alleviate much of their anxiety.

Antibiotic prophylaxis  Previous section Next section

Prophylactic antibiotics are administered to children following the national guidelines.

Bowel preparation  Previous section Next section

The most difficult preprocedure activity is to prepare the bowel so it can be adequately visualized. A number of different regimes are available that are based either on wash out of the bowel (lavage) or cathartics. Both methods are subject to failure because they usually rely upon the cooperation of the infant or child and even best efforts of the medical staff may be frustrated in getting the infant or child adequately cleaned out.

Purge methods  Previous section Next section

In infants, the best technique usually involves clear liquids and milk of magnesia. Milk of magnesia 1.0 mL/kg of body weight is given two nights before the procedure and mid-day the day before the procedure.

Magnesium citrate may also be used in children above one year of age. This may be divided in two doses and given 24 and 12 hours before the colonoscopy. It is best given cold and over ice, or mixed with lemon-lime type soft drinks. Some individuals become nauseated with this and other cathartics. It is often better accepted if the dose of magnesium citrate is divided in four fractions taken over a four-hour period of time.

The night before the colonoscopy, we often prescribe a glycerin suppository to enhance evacuation.

The above preparation regimen is probably the most benign of the various methods available and is the one with which the infant or child is most likely to cooperate.

Lavage methods  Previous section Next section

In the lavage methods the patient is allowed to eat and drink up until the afternoon before the procedure. The patient then fasts for four hours. We prefer a flavored lavage solution which contains a nonabsorbable agent such as sorbital or mannitol. 5–10 mL/kg up to 250 mL is given by mouth every 10 minutes, and is continued until the rectal effluent is clear.

A large volume-balanced electrolyte lavage solution may also be administered. The dosage may be split so that half is given the day prior to the examination, and the rest on the day of the procedure. Some adolescents and teenagers will accomplish taking this solution readily. In the younger age child, however, success is less assured. Hospitalization for 24–48 h may be necessary before the procedure to cleanse the colon in uncooperative patients, where the placement of a nasogastric tube into the stomach may be the only way to guarantee administration of the solution. A randomized study of 2 doses of sodium phosphate vs. a large (4 L) polyethylene-glycol preparation was performed in pediatric patients. Compliance was easy or tolerable in 80% of the phospho-soda group but in only 33% of those who took the electrolyte prep. The bowel was well prepared in almost all of the former, but in only 40% of the group who were given the large volume prep. Asymptomatic hyperphosphatemia was noted in the patients who took sodium phosphate.

If the child vomits in response to the lavage, the rate of infusion may have to be curtailed. Continuous nasogastric tube infusion of the large volume electrolyte solution over a period of 12 hours is very effective if children vomit the solution when it is given rapidly. During the infusion, metoclopramide 0.1 mg/kg is given to a maximum of 10 mg 20minutes prior to lavage and every four hours to enhance gastric emptying.

Overdistention of the stomach or slow gastric emptying should be suspected if stool is not passed within the first four hours after starting the lavage technique. The rate of infusion of the balanced electrolyte lavage solution is usually between 100 and 200 mL per hour up to a full volume of four litres. We typically give an infusion into a peripheral vein to provide maintenance fluids and electrolytes.

Enema  Previous section Next section

Enemas should not be used if the colonoscopist is looking for evidence of inflammatory bowel disease in the rectum and sigmoid colon since enemas often cause erythema of the colonic mucosa and petechiae, giving a false-positive macroscopic image.

Equipment  Previous section Next section

Pediatric colonoscopes less than 11 mm in outer diameter are commercially available. They have a 3.2-mm biopsy channel, which allows the use of all accessories, such as standard biopsy forceps, snares, needles, and thermal probes. Colonoscopes with adjustable stiffness are more suitable for children over four years of age.

Colonoscopes specifically designed for infants and toddlers do not exist. Instead, pediatric upper GI endoscopes can be used. Although it is more difficult to telescope the sigmoid colon with these instruments, higher flexibility and smaller diameter prevent excessive stretching of the bowel, especially in infants.

Medication  Previous section Next section

The child and one, or both parents or grandparents, may be brought to the pre-endoscopy area, where an intravenous infusion is started. In order to minimize the discomfort of the intravenous needle, Emla cream may be applied to three or four potential intravenous sites 45 min before an angiocath is placed into a peripheral vien.

Full and continuous monitoring is necessary during the procedure. Sedation is begun after baseline vital signs are obtained.

Sedation  Previous section Next section

The most commonly used sedation for colonoscopy includes use of tranquilizers for relief of anxiety and narcotics for sedation-analgesia.

The narcotic of choice is Fentanyl, which is rapid acting with a short half-life and minimal side-effects. It rarely causes nausea and vomiting and does not lower the seizure threshold. Doses typically are 4 µg/kg given in 1 µg/kg boluses every 2–3 min This regime is continued until a state of sleepiness is reached or the patient, when asked to count to 10 cannot complete it.

Midazolam (Versed) is the most commonly used tranquilizer in children because of its speed of action and effectiveness. Doses range from 0.15 to 0.30 mg/kg given in divided doses. Midazolam is administered and each dose is flushed in with normal saline.

A two-minute time interval subsequent to each dose of medication is allowed before the patient is either questioned or (if old enough) asked to count from 1 to 10 and then backwards from 10 to 1.

If after giving a total dose of 4 µg/kg of fentanyl and 0.3 mg/kg of midazolam the patient is still awake, not sleepy and can count coherently, promethazine may be given. The dosage used is 1 mg/kg up to 25 mg. Additional sedation with midazolam or fentanyl may be needed during the procedure.

Anesthesia  Previous section Next section

Anesthesia may be necessary if routine sedation is not successful. Agents such as ketamine and propofol may be necessary but they are best and most safely administered by an anesthesiologist. Many pediatric gastroenterologists do not use sedation-analgesia, and perform all cases under propofol anesthesia given by the anesthetist.

Technique of colonoscopy  Previous section Next section

Following sedation the patient is placed in the left lateral decubitus position. The parents are asked to leave the room once the patient is sedated. We do not make it a practice to allow parents to stay for the procedure.

Complete colonoscopy can be performed successfully in the majority of children. Many factors can influence and complicate the procedure, e.g. redundant large intestine, improper preparation, previous surgeries, etc. It is important to understand the general principles of pediatric colonoscopy.

Guidelines  Previous section Next section

Guidelines for safe and effective colonoscopy are:

  • The intubated colon adopts configuration and shape according to manipulations and movements with the colonoscope, and the pattern of these changes are predictable, as well as the direction in which the colonoscope tip should be moved.
  • Rotation, twisting, withdrawal, and simultaneous to and fro movements of the shaft will prevent formation of big 'loops', mesenteric stretching, and related abdominal pain and discomfort.
  • Excessive insufflation leads to overdistention and diminishes ability to telescope the bowel.
  • During the procedure, the patient's comfort is provided by appropriate anesthesia, as well as optimal technique of colonoscopy. Excessive pushing forward creates more problems than benefits for the endoscopist.

The principles of pediatric colonoscopy are similar to those in adults, but because of the child's small stature, angulations may be more acute. In the child, it is often possible to palpate a loop of the scope in the abdomen, a clue that instrument withdrawal and straightening are needed. Meticulous attention to technique is required in children because the colon wall is thin, and, in the presence of anesthesia using propofol, there may not be any noticeable feedback from the patient that would provide a clue as to pain or discomfort from an overstretched mesentery or overdistended bowel (Fig. 3).

The key to effective colonoscopy is to minimize pain and discomfort. It is critical to try and keep the lumen of the bowel in sight knowing where the tip of the colonoscope is and trying to keep the colonoscope straight with avoidance of loops.

The mucosal pattern of the colon is best evaluated as the instrument is slowly withdrawn. However, we think it is important to carefully look at the mucosa while advancing forward, since trauma can sometimes occur to the mucosa with the passage of the instrument, and if abnormalities are not identified beforehand, one is always left wondering whether what one sees is due to colonoscopy, vs. the underlying pathology.

Risks and complications of colonoscopy  Previous section Next section

The potential risks and complications of colonoscopy include bleeding, perforation, infection, and difficulties with sedation (such as paradoxical reaction to the agent used). A higher dose of analgesic medication may be required for colonoscopy, vs. upper intestinal endoscopy, because procedures involving the colon may produce more intensive pain and/or require longer procedure time. The higher doses of medication require careful monitoring because there may be a limited margin between inadequate sedation and oversedation.

Bowel perforation and hemorrhage related to pediatric colonoscopy are serious but rare complications of colonoscopy. During diagnostic colonoscopy the estimated frequency of colonic perforation, most commonly in the sigmoid, is in the range of 0.2–0.8%. This is an extremely low risk of perforation. The frequency is higher with therapeutic colonoscopy procedures such as polypectomy but is still comparatively rare ranging from 0.5 to 3%. Mortality is extremely low and should be substantially less than 0.2%.

Top of page Indications for colonoscopy  Previous section Next section

Rectal bleeding in children  Previous section Next section

Careful history and physical examination may suggest the correct diagnosis such as recent exposure to antibiotics (antibiotic associated colitis), perianal streptococcal cellulitis, or an anal fissure. Allergy to cow's milk or soy protein may cause rectal bleeding in the absence of any other symptoms. Every child with hematochezia does not require colonoscopy. Perianal fistulas, skin tags, and hemorrhoids are indicative of Crohn's disease in children less than 18. Fissures are caused by passage of large bulky stools, with bright red blood on the outside of stool or mixed with the fecal stream if unformed.

Stool studies on every patient who has rectal bleeding should include a smear for polymorphonuclear leukocytes. Bacterial culture is indicated if leukocytes are present (Shigella, Salmonella, Campylobacteria, E. coli, and Yersinia enterocolitica). If antibiotics have been taken in the past three months, Clostridium difficile toxin titres (A and B) should be requested. The parasitology lab should look for Entamoeba histolytica and Trichurus trichura. The presence of eosinophils and Charcot–Leyden granules indicates allergic colitis.

In the pediatric patient with persistent or recurrent hematochezia and no identifiable cause, colonoscopy or flexible sigmoidoscopy is the procedure of choice to search for mucosal changes or other lesions associated with bleeding. Twenty-five percent of patients at colonoscopy who have colitis will have unclassified microscopic changes. Nodular lymphoid hyperplasia of the colon typically seen in early infancy is characterized by umbilicated lesions in the rectum, sigmoid, and/or colon.

Pain accompanying rectal bleeding may be caused by anal fissures, but intermittent cramping pain and the passage of 'currant jelly-like' stool should raise the suspicion of intussuception, although dark or red blood may be seen. Vasculitis of the Henoch–Schonlein type typically presents with skin lesions, but the patient may have only abdominal pain and rectal bleeding. Endoscopic biopsy may be diagnostic when taken from areas of bleeding or from ulcerations.

Chronic diarrhea  Previous section Next section

Nonbloody diarrhea is an uncommon indication for colonoscopy unless it is chronic and the stool cultures and ova/parasites have been nondiagnostic. Approximately 5% of patients who have colitis will not have polymorphonuclear leukocytes present in their stool. Microscopic colitis has been described in children presenting with chronic diarrhea, abdominal pain, loss of appetite, and weight loss. Multiple biopsies should be taken from the small bowel and colon in the patient with chronic diarrhea even if no abnormality is visible to gross visual inspection.

Inflammatory bowel disease, colitis, and cancer  Previous section Next section

Clostridium difficile may show characteristic pseudomembranes, however, this is not pathognomic for this bacteria and it may also be seen following Shigellosis. Allergic colitis that is more typically seen in young infants may be nonspecific. Polyps, foreign bodies, and internal trauma from abuse may all be identified at colonoscopy. Lesions such as angiectasias or rectal varices may also be visualized. Cathartic abuse may also be recognized by the typical tigroid stripes seen in the mucosa.

The importance of colonoscopy in patients with inflammatory bowel disease is to define the extent of the inflammation, to obtain tissue samples that may establish the specific diagnosis, and as an aid in planning therapy.

Development of adenocarcinoma of the colon in children is extremely rare but does occur even in children who never had ulcerative colitis. It typically presents with intermittent rectal bleeding and no diarrhea or with a progressive change in stool caliber.

The determining factor in the development of cancer in ulcerative colitis seems to be related to three factors: the severity of the original attack, the extent of mucosal involvement, and the duration of colitis. The cancer risk for patients with universal colitis involving the entire colon is not dependent on the age of onset, so children are at risk who have the disease for about 8 years, and even young persons with universal colitis should begin surveillance colonoscopy after 8 years of disease. Children of patients with inherited polyposis syndromes should have a surveillance colonoscopy to identify the presence of polyps and this is recommended to begin at 11 years of age.

Therapeutic colonoscopy  Previous section Next section

Juvenile or inflammatory polyps are not uncommon in children. They are most common in the 4–6 years age group but may be present as early as age 1 year. They are uncommon after age 18. Although autoamputation may occur in these cases many will not spontaneously disappear. This is the reason why when patients present with rectal bleeding and polyps are suspected, colonoscopy is indicated to remove the polyp with snare and cautery. The bleeding is usually painless, but the only symptoms may be anaemia from more proximal polyps although most polyps are in the left colon.

Hereditary polyposis syndromes are often confirmed by following the patient colonoscopically and by doing polypectomy.

Top of page Summary  Previous section Next section

Colonoscopy in children is different from colonoscopy in adults. The preparation must be more carefully explained to the parents or guardians, and compliance can often be a problem. The equipment is the same as used in adults, but a gastroscope can be quite useful for negotiating acute angulations. The technique of the examination is similar, but the bowel wall is quite thin and may not withstand the formation of large loops. The pathology in children as well as indications for colonoscopy are also different from that found in adults with rectal bleeding being the commonest indication, and neoplastic disease being the least likely pathology finding. With adequate sedation, careful monitoring, and meticulous attention to technique, colonoscopy in children can be a safe and rewarding procedure.

Top of page Suggested reading  Previous section

Arain, Z & Rossi, TM (1999) Gastrointestinal bleeding in children: an overview of conditions requiring nonoperative management. Semin Pediatrics Surgery 8, 172–80.

Dillon, M, Brown, S, Casey, W, Walsh, D, Durnin, M, Abubaker, K & Drumm, B (1998) Colonoscopy under general anesthesia in children. Pediatrics 102, 311–83.

Fox, VL (1996) Colonoscopy. In: Walker, WA, Durie, PR & Hamilton, JR. Pediatric Gastrointestinal Disease, 2nd edn. St. Louis: Mosby,: 1533–41.

Fox, VL (2000) Pediatric Endoscopy. Gastrointest Endosc Clin N Am 10, 175–94 PubMed

Gillett, P & Hassall, E (2000) Pediatric gastrointestinal mucosal biopsy. Special consideration: in children. Gastrointest Endosc Clin N Am 10, 669–712. PubMed

Greenson, JK (2002) Dysplasia in inflammatory bowel disease. Semin Diagn Pathology 19, 31–7.

Gremse, DA, Sacks, AI & Raines, S (1996) Comparison of oral sodium phosphate to polyethylene glycol-based solution for bowel preparation for colonoscopy in children. J Ped Gastroenterol Nutr 23, 586–90.

Hassall, E, Barclay, GN & Ament, ME (1984) Colonoscopy in childhood. Pediatrics 73, 594–9. PubMed

Michaud, L, Gottrand, F & Ganga-Zandzou, PS, et al. (1999) Nitrous oxide in pediatric patients undergoing gastrointestinal endoscopy. J Ped Gastroenterol Nutr 28, 310–14.

Provenzale, D & Onken, J (2001) Surveillance issues in inflammatory bowel disease: ulcerative colitis. J Clin Gastroenterol 32, 99–105. PubMed

Rothbaum, RJ (1996) Complications of pediatric colonoscopy. Gastrointest Endosc Clin N Am 6, 445–59. PubMed

Snyder, J & Bratton, B. (2002) Antimicrobial prophylaxis for gastrointestinal procedures: current practices in North American academic pediatric programs. J Ped Gastroenterol Nutr 35, 564–9.

Tanaka, M, Masuda, T, Yao, T, Saito, H, Kusumi, T, Nagura, H & Kudo, H (2001) Observer variation of diagnoses based on simple biopsy criteria differentiating among Crohn's disease, ulcerative colitis, and other forms of colitis. J Gastroenterol Hepatol 16, 1368–72. PubMed

Trautwein, AL, Vinitski, LA & Peck, SN (1996) Bowel preparation before colonoscopy in the pediatric patient: a randomized study. Gastroenterol Nurs 19, 137–9. PubMed

Copyright © Blackwell Publishing, 2004

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Synopsis
Classification of indications
  Diagnostic vs. therapeutic
  High-risk vs. low-risk
  High-yield vs. low-yield
Alternatives to colonoscopy
Specific indications
  Bleeding
   Colonoscopic treatment of bleeding
  Abdominal pain and constipation
  Chronic diarrhea
  Abnormal radiographs or sigmoidoscopy
  Established ulcerative colitis
   Surveillance in ulcerative colitis
  Established Crohn's disease
  Surveillance after colonoscopic polypectomy
  Surveillance after cancer resection
   Timing of surveillance
   Rectal cancer
  Screening average risk subjects
  Miscellaneous indications
Contraindications to colonoscopy
  Absolute contraindications
  Relative contraindications
Conclusion
References
Synopsis
  Higher risk subjects
  Average-risk subjects
Rationale for screening
  Fecal occult blood test (FOBT)
  Flexible sigmoidoscopy
   Limitations of screening by flexible sigmoidoscopy
  Combined flexible sigmoidoscopy and FOBT
  Radiographic colon imaging with barium, CT, or MRI
  The potential for genetic testing
The case for screening with colonoscopy
  Arguments against screening with colonoscopy
  Arguments for screening with colonoscopy
   Does screening colonoscopy reduce mortality?
  Patient acceptance of colonoscopy screening
  Potential harm from colonoscopy
  Resources for screening colonoscopy
Costs of screening for colon cancer
Screening colonoscopy: areas of uncertainty
  Reducing overall mortality?
  Timing of colonoscopy screening
   When to repeat screening?
  Will screening colonoscopy be superseded?
Conclusion
References
Synopsis
Factors suggesting difficulty in polypectomy
  Polyp size
  Malignant potential
  Configuration
   More than one-third of the circumference
   Polyps crossing two haustral septae
   Polyps involving the appendiceal orifice
  Bleeding risk
Practice issues for difficult polyps
  Risks and consent
  Ambulatory or in-patient polypectomy
  Which colonoscope for difficult polyps?
  Sometimes a thinner endoscope is helpful
  Which snare?
   Types of snares
   Use of the mini snare
  Submucosal injection for polypectomy (SIP)
   Injection fluid
   Injection site
   Polyps behind folds
   Injection volume
   The non-lifting sign
   Tumor tracking
  Cap assisted polypectomy
Polyp resection technique
  Stop at the line
  Piecemeal polypectomy
  Positioning the polyp
  Clamshell polyps
   Retroversion
  Flat polyps
  Residual fragments of adenoma after polypectomy
Judging and marking the location of lesion
  Location by depth of insertion
  Endoscopic landmarks
  Clipping
  Marker injections into the colon wall
   Indocyanine green
   India ink
  Intraoperative colonoscopy
  Radiological methods of localization
   Barium enema
   Magnetic imaging
The extremely difficult colonoscopy
References
Synopsis
Pathology
  Definition of malignancy and polyps
  Assessment of polyps
Risk factors for malignant polyps
  Polyp size and villous component
   Polyp size
   Pathology
   Dysplasia
  Flat lesions
   Are flat lesions missed in the West?
Initial endoscopic evaluation and treatment of polyps
  Visual assessment
  Difficulties after resection
  Localization of polyps, tattooing
Surgery or endoscopic follow-up?
  Pedunculated adenomas
   Factors suggesting no need for surgery
   Factors favoring surgery after polypectomy
   What is a safe margin?
  Sessile adenomas
Role of the clinician
  Follow-up protocols
  Balancing the risk of surgery
  Rectal lesions
  Patients with family history
Conclusion
References
Synopsis
Definitions
  The spectrum of nonpolypoid lesions and their morphogenesis
  Endoscopic criteria
  Pathological criteria
The epidemiology of flat and depressed lesions in the West
  Sweden
  Germany
  United Kingdom
  North America
   Vancouver
   Nebraska
   Galveston
The biological and clinical significance of flat lesions
  Flat lesions or really just small polyps?
   Nomenclature issue
   USA national polyp study
   Flat lesions are different
  Association of flat lesions with advanced pathology
  Depressed lesions are more important than simple flat lesions
  'De novo' colorectal cancer and the relationship between early cancer and F & D lesions
  Differences in genetic and biological markers between flat and polypoid lesions
  Colorectal carcinogenesis and F & D lesions
   A different genetic pathway?
The challenge of endoscopic detection of F & D lesions
Conclusion and clinical approach
References
Synopsis
Resuscitation and initial evaluation
  History and physical examination
  Medication history
Diagnostic evaluation
  Gastric lavage/aspiration
Bowel preparation
Endoscopes and other equipment
  Colonoscopes
  Hemostatic accessories
  Tissue marking
  Coagulation probes
Study results
  Patients admitted for hematochezia
Specific lesions
  Diverticular hemorrhage
   Comparing surgery with colonoscopic treatment
  Internal hemorrhoids
   Treatment of severe hemorrhoidal bleeding
  Ischemic colitis
   Clinical presentation
   Diagnosing ischemic colitis
   Treatment for ischemic colitis
  Solitary rectal ulcer syndrome
   Colonoscopic therapy
  Postpolypectomy hemorrhage (delayed)
   Incidence of postpolypectomy hemorrhage
   Colonoscopy findings
   Treatment for postpolypectomy hemorrhage
  Colonic angiomas
   Bicap or heater probe study in treatment of bleeding angiomas
   Findings at colonoscopy
   Techniques for hemostasis
   Results
Conclusion
   Acknowledgements
References
Synopsis
Characteristic endoscopic findings in inflammatory bowel disease
  Crohn's disease
   Distribution
  Aphthous ulcer
   Ulcers and cobblestoning
   Strictures and fistulae
   Vascular pattern
   Upper GI involvement
  Ulcerative colitis
   Distribution
   Endoscopic appearances
  Differentiation between Crohn's disease, ulcerative colitis, and indeterminate colitis(Fig. 12)
Endoscopic assessment of extent and severity of inflammatory bowel disease
Endoscopic monitoring of therapeutic efficacy and its value in clinical trials
Perioperative endoscopy in Crohn's disease
Endoscopic features of the ileoanal pouch and pouchitis
Endoscopic treatment of Crohn's disease complications
Conclusion: the role of endoscopy in IBD(Fig. 14)
References
Synopsis
Indications for colonoscopy
When diagnostic colonoscopy is not indicated
Preparation of the patient for colonoscopy
  Explanation
  Antibiotic prophylaxis
  Bowel preparation
   Purge methods
   Lavage methods
   Enema
  Equipment
  Medication
   Sedation
   Anesthesia
  Technique of colonoscopy
   Guidelines
  Risks and complications of colonoscopy
Indications for colonoscopy
  Rectal bleeding in children
  Chronic diarrhea
  Inflammatory bowel disease, colitis, and cancer
  Therapeutic colonoscopy
Summary
Suggested reading
Synopsis
Aids to advancing a colonoscope
  Overtubes
  Internal spines
  Mother-and-baby colonoscope systems
  Thread-guided pull endoscopy ('rope-way' colonoscopy and enteroscopy)
Friction reduction
  Lubricating the endoscope
  Vibrating the shaft of the endoscope
  Everting toposcopic endoscopy
Novel propulsion systems
  Balloons to grip the wall—Earthworm
   Potential damage to the colon wall
  Suction crawler—Limpet or starfish
  Serpentine robot—Snake
  Many legs—Millipede
  Few legs—Lizard and ant
  Water jet—Octopus
  Wheels and belts
Wireless capsule colonoscopy
Future needs in other areas related to colonoscopy
  Sedation
  Bowel preparation
  Instrument disinfection
  New imaging methods
The future of therapeutic colonoscopy
Conclusion
Acknowledgments
References

Blackwell Publishing


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